Whenever amines are used in the formulation of a product, impurities of secondary amines might be the cause of nitrosamine generation. Using a variety of raw materials and not knowing the exact manufacturing process of those substances, there often is no obvious source for nitrosamines. Ensuring the absence of nitrosamines at a given detection limit can only be accomplished via comprehensive screening of all materials involved.
May 1, 2020 Düsseldorf / Germany
Avoiding Nitrosamines in Production
Nitrosamine Testing at Henkel Corporate Analytics
For the analysis of nitrosamines in various matrices, we make use of two different, highly sensitive methods:
- Total-N-Nitroso determination (non-specific screening procedure)
This procedure yields a worst-case maximum value: all nitrosamines are taken into account due to their characteristic nitroso moiety. Negative test results at appropriate detection limits ensure the highest safety margin as this procedure also includes unexpected and unknown nitrosamines. - Substance-specific determination
Nitrosamines may be formed as by-products during synthesis of the active ingredient. Knowledge of the manufacturing process helps understand what type of nitrosamines to expect. This procedure allows to monitor their formation and to define adequate countermeasures in production.
Do you have any other analytical question or are looking for support? Don’t hesitate to call (0211-797 3683) or write to (analytik@henkel.com).
